I've done this for the past couple years. I'm a part of a Pig Skin Pick 'em league on ESPN, and I'll try to post my picks here weekly:
Minnesota Vikings at New Orleans Saints - The game is already underway as I type this, but I made my pick last week. Based of each teams 1st drives, I made a good pick. We'll see in two hours.
Miami Dolphins at Buffalo Bills - I think this will be a close game. C.J. Spiller is going to have a big game and lots of talk about him after this weekend.
Detroit Lions at Chicago Bears - Bears win big. Bears fans start talking big. Bears fans get disappointed as the weeks go on.
Oakland Raiders at Tennessee Titans - It's the Raiders.
Cincinnati Bengals at New England Patriots - I see good things from the Bengals this year. I also hate picking the Patriots to win.
Carolina Panthers at New York Giants - Should go with Giants, but I always pick the Panthers. I really like Deangelo Williams. I think that's why.
Atlanta Falcons at Pittsburgh Steelers - Steelers are going to really struggle for their first 4 weeks.
Cleveland Browns at T.B. Bucs - Would you rather throw up or have diarrhea? Similar choices here.
Denver Broncos at Jacksonville Jaguars - Jags don't look good, but neither do the Broncos. I give Jags the edge because they're at home and will likely struggle with the time zones.
Indianapolis Colts at Houston Texans - Won't be shocked if the Texans win. If my predictions are right, Texans are the only team in their conference with a loss in week 1. Texans will have a winning record by the end of the season.
San Francisco 49ers at Seattle Seahawks - I just can't pick against Mike Singletary.
Green Bay Packers at Philadelphia Eagles - Step 1 in the Kevin Kolb experiment fail.
Arizona Cardinals at St. Louis Rams - Derek Anderson, my sleeper of the year.
Dallas Cowboys at Washington Redskins - Shanahan... underrated. All things Cowboys... overrated.
Baltimore Ravens at New York Jets - In my book, best game of the week. I want to see the Ravens make the Jets and Rex Ryan look real dumb.
San Diego Chargers at Kansas City Chiefs - Chiefs could be better than expected. Not this week.